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Our Silver-Coated Future

(Page 3 of 5)

But might exposure to nanoscale particles of silver have more pernicious side-effects? It's hard to say, because few studies have been done specifically on nanosilver. Despite this uncertainty, consumer products with nanosilver keep being introduced. And without any requirements for premarket safety testing, manufacturers have no incentive to conduct such tests on their own.

At the moment, the health risks of nanosilver are conjectural, based on what little is known about how other nanoparticles behave. But this is an imperfect system, since we can't be sure whether one nanoparticle's tendency to penetrate individual human cells predicts how a different nanoparticle -- even a slightly different size or shape of the same basic nanomaterial -- will behave.

What we know at this point is merely suggestive, but in some cases worrisome. One study of cells in culture, for instance, showed that when human lung tissue is exposed to carbon nanotubes, the lung cells see these not as foreign agents but as a biological substrate on which to build other tissue. Rather than mounting an immune response to attack the nanotubes as invaders, the lung cells start building layers of collagen around them. No one can say how likely it is in real life for carbon nanotubes to be inhaled; for most current uses, such as lightweight bicycle parts or tennis rackets, they are fixed in a matrix. But there is a chance that they might be inhaled during manufacture or as the product degrades, either through normal wear and tear or after it's disposed of. If they get into people's lungs, will carbon nanotubes act in vivo the way they do in cell culture, and become a scaffolding for new layers of collagen that could block the airways?

Similar questions about the safety of nanoparticles arise from animal models showing that they can get into the bloodstream through the skin and then travel to vital organs, including the brain. As with airborne exposure, the likelihood of skin expsure to carbon nanotubes is still an unknown, but once again early research indicates that there could be some health effects. Toxicologist Günter Oberdörster of the University of Rochester, working with rodents, found that carbon nanoparticles were small enough to enter the brain by way of the olfactory nerve, circumventing the blood-brain barrier, the usually impermeable membrane that protects the brain from foreign agents.

The main thing that is known about the toxicology of nanoparticles is how much remains to be discovered. Nanoparticles, says Maynard, "can penetrate into cells in ways that larger particles cannot, or migrate to places in the body large particles cannot get to."

Another worrisome finding is a possible link between nanoparticles and the more rapid formation of protein fibrils, a material found in neurons that, when it accumulates, can lead to the buildup of a brain toxin called amyloid. Chemists from several European universties, led by Sara Linse of University College Dublin, exposed a laboratory preparation of purified protein to four types of nanoparticle, including carbon nanotubes and so-called quantum dots (crystals just 5 or 10 nanometers in diameter that are used in the semiconductor industry to measure electric current down to the level of the electron). All four types of nanoparticle accelerated the abnormal development of the protein into amyloid fibrils. The reason for the concern is that amyloid has been implicated in a variety of neurological diseases, including Alzheimer's and Parkinson's.

As with most studies in nanotoxicology, the Linse study is preliminary; it was conducted in vitro, not in an animal or a human, and it remains to be seen whether the findings will be replicated in vivo. But it does point out the complexity of the emerging field of nanotoxicology.

"One of the most important messages of this work for chemists," wrote Vicki Colvin and Kristen Kulinowski of Rice University in last May's Proceedings of the National Academy of Sciences, "is that when NP's [nanoparticles] enter the biological world they become very different materials." According to Colvin and Kulinowski, "The small sizes of NP's convey the potential to access many biological compartments, where they are met with a smorgasbord of possible binding partners from the coplex and concentrated soup of biomolecules."

In terms of environmental consequences, if nanosilver is anything like ordinary silver, we might be in for some trouble. As with the potential human health risks, the environmental dangers can only be guessed at by analogy -- in this case, to the known impact of normal-scale silver on aquatic organisms. According to Samuel Luoma, a senior research scientist at the U.S. Geological Survey in Menlo Park, California, silver is a powerful environmental toxin, second only to mercury in the damage to invertebrates that even trace amounts can do. It kills microorganisms indiscriminately and can wipe out the beneficial ones as well as the pathogenic ones. In addition, it has a direct effect on the reproductive capabilities of certain aquatic invertebrates, and possibly fish as well.

Through most of the 1980s, says Luoma, silver pollution from a photo-processing plant led to widespread sterility among the Macoma balthica clams in South San Francisco Bay near Palo Alto. Clams are an important part of the bay-bottom food web, he says, and the population recovered only when new regulations limited the amount of silver in the bay. The photo-processing plant was eventually closed.

The lesson learned was a crucial one: It took a very low concentration of silver, less than one part per billion, to destroy the reproductive organs of virtually all adult M. balthica living within a certain distance of the silver source, and to spread silver contamination throughout the South Bay.

"No one outfall [the sewage pipe that carries wastewater from a treatment plant] could have effects everywhere in San Francisco Bay," Luoma says. "The risk with nanosilver from consumer products is that it would come from all outfalls that serve urban customers. What we need to know is how much silver would be released from many households. Would it be comparable to the mass from photo processing?"

Silver might have been especially toxic in San Francisco Bay because the bay is salt water. Unlike many other environmental toxins, silver seems to be more dangerous in salt water than in fresh. In freshwater, silver combines with chloride and forms a solid that sinks to the bottom, becoming less bioavailable (that is, less capable of absorption by the body). But in salt water, with a preponderance of chloride atoms, more silver chloride remains in solution, binding to particulate matter. This puts more of it into the food chain and therefore makes it more likely to do damage to marine organisms.

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Robin Marantz Henig is a contributing writer to the New York Times Magazine. She is the recipient of a 2009 Guggenheim Foundation fellowship, and is the author of eight books on science, including The Monk in the Garden (Houghton Mifflin), a finalist... READ MORE >

I went through this article and found it very interesting and informative.Especially the various aspects the article has gone through like environment,health,energy production, cosmetics almost every part of we human being use. I expect more article of this kind.But there should be more positive points related to use of nanotechnology in relation to human health rather than counting its harmful effects.

very interesting, elloborate and informative. Can include more on side effect / safety on man kind etc..

I am really surprised to know the nano concept.I think in future everything will be manufacture by nano technology.
But what will be the side effect?

this is an intersting and uefull article regarding side effects of excess and blind use of nanoparticles theory.it draws our attention to concern about all the usage and reserch in the nanofield.this article muct be taken seriously by the govrment in all nations.as it puts light on the what effect can it do to human health and environment.we need to care about this before moving any further steps.

The article given in this is so useful for every one who want might advance information about nanotech. Iam thankful to writer who wrote this

I am a current Computer Sciences student who has recently read this article. The information contained in this article has helped me to begin my research on my final project that involves the use of nanotechnology. In all honesty, I have found the material in this article to be more informative than any other source I have researched.

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